Carlton will take on the Kangaroos in a preliminary final, after a convincing 29-point win over Brisbane.
Harris was crucial in the 6.8 (44) to 2.3 (15) win, crashing packs all afternoon to open the game up for the small forwards.
The Lions dominated the game in the early stages, but it was Darcy Vescio who stepped up for the Blues with seven disposals and a goal in the second quarter, providing a spark to shift the momentum of the game.
Carlton speedster Georgia Gee registered just three disposals in the first half, but the forward came to life with two third-quarter goals to give Carlton a comfortable lead.
Blues defender Kerryn Harrington was the best player on the ground for most of the afternoon, but the 27-year-old gave away a silly kick which allowed Jesse Wardlaw to kick a goal and give the Lions some hope heading into the final quarter.
A heartbreaking result in Melbourne today bringing our 2020 season to an end. Thank you for all the support from home today Lions fans! #AFLWBluesLions pic.twitter.com/HNHglnTbLf
— Brisbane Lions AFLW (@lionsaflw) March 22, 2020
Gee iced the game with her third goal in the final term, dashing any hopes the Lions had of a comeback.
Carlton midfielder Maddy Prespakis was electric early with eight disposals in the first term, but the young gun limped off with an ankle injury at the end of the third term and struggled to hit top speed when she returned in the fourth quarter.
CARLTON 1.0 2.2 4.6 6.8 (44)
BRISBANE 1.2 1.2 2.3 2.3 (15)
GOALS
Carlton: Gee 3, Harris, Vescio, McEvoy
Brisbane: Wuetschner, Wardlaw
BEST
Carlton: Harrington, Prespakis, Gee, Vescio, Dalton, J.Hosking
Brisbane: Anderson, Lutkins, Bates, Svarc, Wuetschner, Conway
INJURIES
Carlton: Prespakis (ankle)
Brisbane: Campbell (back)
LATE CHANGES
Carlton: Nil
Brisbane: Nil
Reports: Tayla Harris was reported for rough conduct on Emily Bates.