Brisbane has set a record for the biggest AFLW score but fell agonisingly short of posting three figures in a 74-point pummelling of West Coast.

The defending champions led 46-0 at half-time before cruising to the 15.8 (98) to 4.0 (24) victory at Mineral Resources Park on Sunday.

Brisbane's total eclipsed the previous record score of 13.9 (87) set by Carlton against Gold Coast in round eight last year.

The Lions had the chance to become the first team to reach triple figures, but Greta Bodey's 38m set shot with less than three minutes remaining drifted just wide.

The result improved Brisbane's record to 6-2, lifting them to fourth spot and moving them to within a win of second-placed Melbourne.

The 30 percentage points they gained could prove crucial in the race for top-two and top-four berths.

West Coast (1-7) are now last on the ladder following St Kilda's shock three-point win over Gold Coast earlier in the day.

Star Lions midfielder Emily Bates finished with 31 disposals and seven clearances in a best afield display, while forward Jesse Wardlaw and Sophie Conway booted three goals apiece.

West Coast skipper Emma Swanson fought hard for 22 disposals and six clearances, but the midfield were outgunned by Brisbane's star-studded on-ball brigade.

Brisbane set the tone of the match in a brutal first quarter in which they amassed 15 inside 50s to 0 and piled on four unanswered goals.

The pain continued in the second quarter as Wardlaw booted her second and third goals.

There were a number of records set in the half-time stats.

The 46-point margin was the biggest-ever half-time lead, West Coast's two inside 50s was the lowest-ever in a first half, and Bates' 22 disposals was the highest first-half tally.

West Coast's first inside 50m entry didn't come until midway through the second quarter, and their first score didn't come until Dana Hooker kicked a goal early in the third quarter.

By then the game was already over.

Brisbane suffered a heartbreaking three-point loss to Melbourne on Monday when Bodey's set shot after the final siren fell just short.

They used the pain of that defeat to put West Coast to the sword in 32-degree heat in Perth.

The only downer to come out for the match for Brisbane was Orla O'Dwyer's right shoulder injury.

O'Dwyer, who already had her shoulder strapped, suffered the injury while attempting a tackle and immediately left the field cradling her right arm.

Hooker went off late for West Coast with a leg injury.

WEST COAST             0.0      0.0      2.0        4.0 (24)
BRISBANE                  4.3      7.4      11.4      15.8 (98) 

GOALS
West Coast: Hooker, Bullas, Gooch, Cameron
Brisbane: Wardlaw 3, Conway 3, Hodder 2, Bodey 2, Davidson, Smith, C.Svarc, Dawes, Ellinger 

BEST 
West Coast: Swanson, Lewis, Bowen
Brisbane: Bates, Anderson, Wardlaw, Conway, C.Svarc, Hickie 

INJURIES 
West Coast: Hooker (lower leg)
Brisbane: O’Dwyer (shoulder)

LATE CHANGES
West Coast: Nil
Brisbane: Nil

Reports: Nil

Crowd: TBC at Mineral Resources Park