Rich has been sidelined since Round 14 with a stress reaction in his foot, but made a successful return through the Lions Reserves last Saturday which earned him a senior recall.
The 21 year-old replaces James Hawksley in the only change to the Lions team that defeated the Gold Coast SUNS in QClash 2 last Saturday night at the Gabba.
Young Lions Mitch Golby, Patrick Karnezis and Niall McKeever have also retained their positions in the side and are now set to play their first senior AFL game at the MCG.
Meanwhile, Aaron Cornelius (1 game), Pearce Hanley (2 games), Todd Banfield (3 games), Sam Sheldon (4 games) and Tom Rockliff (4 games) have a combined total of just 14 games experience at the home of AFL football.
This Saturday night will mark the first encounter between the Lions and reigning Premiers Collingwood since Round 10 of 2010.
The full Lions Round 22 team is listed below:
B: Ash McGrath (9), Matt Maguire (36), Cheynee Stiller (32)
HB: Pearce Hanley (11), Niall McKeever (40), Jed Adcock (7)
C: Tom Rockliff (38), Andrew Raines (29), Daniel Rich (10)
HF: James Polkinghorne (31), Brent Staker (14), Sam Sheldon (3)
F: Todd Banfield (18), Mitch Clark (1), Aaron Cornelius (44)
FOLL: Matthew Leuenberger (23), Simon Black (20), Jack Redden (30)
INT: Luke Power (6), Patrick Karnezis (28), Josh Drummond (39), Mitch Golby (41)
EMERG: James Hawksley (12), Bryce Retzlaff (37), Rohan Bewick (43)
IN: Daniel Rich
OUT: James Hawksley (omitted)
