Senior midfielder Mitch Robinson will miss at least 10 weeks of football with a foot fracture.
Robinson suffered the injury during Sunday's loss to Sydney at the SCG, with scans yesterday revealing the extent of the damage to his right foot.
The 27-year old will wear a moonboot and stay off his feet for the next month.
Robinson, a joint Merrett-Murray Medallist in 2015 and runner up last season, was due to play his 150th match against Hawthorn in his home state of Tasmania on Sunday.
Brisbane Lions General Manager of Football David Noble said: "It's frustrating for Mitch who has had a strong start to the year.
"Mitch is someone who leads by example and shows complete commitment week in and week out - we know that he will show the same commitment to his rehab.
"While he is recovering, Mitch will remain very much involved at the Club, mentoring some of our younger players as well as having involvement in the NEAFL program."
In further injury news, defender Daniel McStay will undergo surgery to repair a fractured hand following Sunday's loss to the Swans.
McStay will have a plate inserted and is expected to miss the next 2-3 weeks.
Lions.com.au will have a full injury update in the Recovery Report later today.