Brisbane is looking to replicate the men's MCG heroics and break its AFLW hoodoo against Narrm on Sunday.
The round four blockbuster will mark the first time the two sides have met since last season, where the Demons dashed Brisbane's hopes in the preliminary final.
Narrm, tipped as the team to beat in season seven, currently sits third on the ladder behind Brisbane and Collingwood on percentage.
Lions midfielder and All-Australian Ally Anderson says the game will be telling of where they stand in the competition.
"I'd say that the others would be watching closely," Anderson told reporters on Tuesday.
"Losing the prelim last year against them, you want to get back and verse them and see what you can do different and see if you can beat them this time.
"It's exciting to come up to a team that we know are really quality and will really give it to us."
The Lions have a poor history at Melbourne's home ground at Casey Fields, just like the men's at the 'G.
The last time Brisbane won there was in their first meeting in 2017. They have lost consecutively on the Dees' patch since, unable to match their opponents' control of rough weather conditions and howling winds.
There was talk about moving the clash to a protected ground like Marvel Stadium, with Brisbane coach Craig Starcevich fully supportive.
"The main thing is if you're going to have two of the better teams in the comp playing in round four, I think in a venue and on a deck that suits the occasion probably is logical sense, really," Starcevich said on Monday.
But the AFLW confirmed that the match will stay at Casey.
Asked whether she still feels any lingering anger or disappointment from last season's preliminary final, Anderson said the game feels like a lifetime ago.
"There's always something there that you're sort of like, 'Oh we could've had that game. We might've gone to the Grand Final' but that's why we play another season," she said.
"It's like any other team - you've got to focus on playing first."
Brisbane's hopes of victory have been bolstered by Melbourne forward and four-time All-Australian Tayla Harris and teammate Jordan Ivey accepting one-game bans after rough conduct charges from last Sunday's 26-point win over St Kilda.
For the duration of AFLW Indigenous Round, the Demons will be rebranded as the Narrm Football Club. Narrm is the Aboriginal name for Melbourne which comes from the Woi Wurrung language, spoken by the traditional owners of the city and its surrounds.